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Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.
General embryology. Developmental biology --- Histology. Cytology --- Oncology. Neoplasms --- oncologie --- cytologie --- embryologie (geneeskunde) --- histologie
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This book describes the embryonic development of the vertebrate inner ear in six chapters that span all aspects of inner ear development, from the induction of the otic placode through cellular morphogenesis, to the onset of auditory function. In each chapter, a particular aspect of development of the inner ear is examined in terms of both classic embryologic experiments and more recent advances using molecular biological techniques. The publication of this volume is particularly timely in light of recent significant advances in molecular biological and cellular imaging techniques. These changes have led to an explosion in the pace of developmental inner ear research that is clearly reflected in the chapters presented here. The book will serve as a useful resource for scientists who study inner ear biology, as well as developmental biologists who work in other systems, but have an interest in an overview of the developing ear. This book will also be a valuable resource for clinicians who wish to know more about the development of the ear and about the genetic and molecular factors that regulate its formation. Matthew Kelley and Doris Wu are both Investigators at the National Institute on Deafness and other Communication Disorders at the National Institutes of Health, Bethesda, Maryland. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago.
General embryology. Developmental biology --- General microbiology --- Biology --- Neuropathology --- neurologie --- biologie --- microbiologie --- embryologie (geneeskunde)
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This book provides two basic concepts on plant propagation and value-added transplant production in a closed structure with artificial lighting: 1) photoautotrophic (sugar-free medium, photosynthetic or inorganic nutrition) micropropagation systems, and 2) closed transplant production systems with minimum resource consumption and environmental pollution. This book also describes the methodology, technology and practical techniques employed in both systems, which have been commercialized recently in some Asian countries such as China and Japan. We often use a closed structure such as a tissue culture vessel, a culture room, a growth chamber, a plant factory with lamps, and a greenhouse to propagate plants and produce transplants. Main reasons why we use such a closed structure is: 1) higher controllability of the environment for desired plant growth, 2) easier protection of plants from damage by harsh physical environment, pathogens, insects, animals, etc, 3) easier reduction in resource consumption for environmental control and protection, and 4) higher quality and productivity of plants at a lower cost, compared with the plant propagation and transplant production under rain, wind and sunlight shelters and in the open fields. Thus, there should be some knowledge, discipline, methodology, technology and problems to be solved on plant propagation and transplant production common to those closed structures, regardless of the types and sizes of the closed structure.
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Health problems such as hypertension, tendency to diabetes, obesity, blood lipids, vascular disease, bone health, behaviour and learning and longevity may be imprinted' during early life. This process is defined as programming' whereby a nutritional stimulus operating at a critical, sensitive period of pre and postnatal life imprints permanent effects on the structure, physiology and metabolism. For this reason, academics and industry set-up the EC supported Scientific Workshop -Early Nutrition and its Later Consequences: New Opportunities. The prime objective of the Workshop was to generate a sound exchange of the latest scientific developments within the field of early nutrition to look for opportunities for new preventive health concepts. Further, a closer look was taken at the development of food applications which could provide (future) mothers and infants with improved nutrition that will ultimately lead to better future health. The Workshop was organised by the Dept. of Pediatrics, University of Munich, Germany in collaboration with the Danone Institutes and the Infant Nutrition Cluster, a collaboration of three large research projects funded by the EU.
General embryology. Developmental biology --- Hygiene. Public health. Protection --- Paediatrics --- gezondheidszorg --- pediatrie --- embryologie (geneeskunde)
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General embryology. Developmental biology --- Histology. Cytology --- Oncology. Neoplasms --- oncologie --- cytologie --- embryologie (geneeskunde) --- histologie
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General embryology. Developmental biology --- General microbiology --- Biology --- Neuropathology --- neurologie --- biologie --- microbiologie --- embryologie (geneeskunde)
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General embryology. Developmental biology --- Hygiene. Public health. Protection --- Paediatrics --- gezondheidszorg --- pediatrie --- embryologie (geneeskunde)
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The attitude to the possibility of regeneration in mammals has changed in recent years to one of cautious optimism that the endogenous mechanisms can be exploited for the medical armentarium. In this volume leading experts discuss the molecular, in vivo and clinical aspects of the use of stem cells in various disease contexts. With the current excitement in the research and clinical communities over the potential of regenerative medicine it is hoped that novel therapies will emerge that target intractable degenerative diseases. The book contains accounts of the latest advances in stem cell biology from the foremost researchers in the field. It discusses the analysis and use of stem cells in basic biology but also their application in clinical practice and is therefore unique in combining basic and applied approaches.
General embryology. Developmental biology --- Histology. Cytology --- Pathology of the circulatory system --- Neuropathology --- hersenen --- cardiologie --- cytologie --- embryologie (geneeskunde) --- histologie
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Each and every hair is much more than just the visible shaft there are also associated complex sheath structures of epidermal and dermal origin. In the hair follicle, cells undergo a variety of differentiation processes, mostly depending on their layers and positions therein, and electron microscopy reveals a very complex architecture. The structure of a particular layer, such as Henle's layer of the inner root sheath, is not uniform. Rather, cells drastically change during the course of differentiation. By simply comparing electron micrographs of cells of a layer at different degrees of differentiation, one can hardly recognize them as belonging to the same layer. As readers will see, this book contains many superb electron mic- graphs, from low-magni?cation panoramic views for orientation to hi- power views showing ultrastructural detail. Captions and schematic drawings are also very helpful in reading electron micrographs and - derstanding the structural detail. In this way, Dr. Morioka has succeeded in dissecting the complex hair follicle at the ultrastructural level.
General embryology. Developmental biology --- Zoomorphology. Zooanatomy --- Pharmacology. Therapy --- Pathological dermatology --- morfologie --- farmacologie --- dermatologie --- toxicologie --- embryologie (geneeskunde) --- zoölogie
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